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  At least two people have died and 17 others were injured after gunmen opened fire outside a nightclub in Fort Myers, Florida.

It comes six weeks after a lone gunman shot dead 49 people at a gay nightclub in Orlando, Florida.

The venue, Club Blu, was  hosting a teen night when the shooting take place, at roughly 12.30am on Monday morning.

Terrified youngsters were forced to "dodge cars and bullets" as they sprinted to safety, the mother of one girl who escaped uninjured said.

Fort Myers police said in a statement that they were "seeking to determine a motive" for the shooting, which appears to have been carried out by at least two gunmen.

Three of the attackers have already been arrested, they added.

There gave no indication as to whether the attack was terror-related.

An attack on a gay nightclub in Orlando, Florida on June 12 left 49 dead in the worst gun massacre in recent US history.

Police killed the gunman, Omar Mateen, a 29-year-old US citizen of Afghan origin, after a three-hour standoff.

The Islamic State jihadist group claimed responsibility for that attack, calling the Mateen "one of the soldiers of the caliphate." US authorities have said he was apparently radicalized after watching jihadist propaganda online.

Most of the victims from Monday morning's mass shooting have been treated and released from the hospital, according to a spokeswoman.

Two victims remain in the Intensive Care Unit, said Cheryl Garn, spokeswoman for Lee Memorial Health Systems.

In total, 18 victims were transported to Lee Memorial hospitals. Of those, one was taken to Cape Coral Hospital and a second was transported to HealthPark.

Marshall Bland said his 23-year-old son's stomach was grazed by a bullet, but he has since been released from the hospital.